Pharmaceutical composition containing combinations of vitamins, minerals, probiotics, and prebiotics effective in preventing adverse effects associated with the use of proton-pump inhibitors

A method of preparation of a pharmaceutical composition that prevents adverse effects associated with the use of proton-pump inhibitors, comprising:

• a) sifting Vitamins D3, K2, and B12 and colloidal silicon dioxide through a #100 mesh;
• b) geometrically diluting the vitamins D3, K2 and B12 in colloidal silicon dioxide and mixing for 5 minutes at each dilution;
• c) sifting microcrystalline cellulose through a #30 mesh;
• d) the geometric dilution of the pre-mix obtained in step b) in microcrystalline cellulose is carried out, mixing for 5 minutes at each dilution;
• e) separately, Lactobacillus acidophilus, Lactobacillus casei, FOS (fructooligosaccharides), and inulin are mixed for 5 minutes after being previously sifted through a #30 mesh;
• f) separately, iron bisglycinate, magnesium oxide, and sodium croscarmellose are mixed for 5 minutes after being previously sifted through a #30 mesh;
• g) calcium citrate malate is placed in a “V” mixer after being previously sifted through a #20 mesh;
• h) the pre-mix obtained in step d) is added to the mixer and mixed for 10 minutes;
• i) the pre-mix obtained in step e) is added to the mixer and mixed for 10 minutes;
• j) the pre-mix obtained in step f) is added to the mixer and mixed for 10 minutes;
• k) the vegetable magnesium stearate, previously sifted through a #60 mesh, is added to the mixer and mixed for 3 minutes;
• and
• l) a “#00” capsule is filled to obtain an average weight of 850 mg per capsule.

A method of treatment to avoid adverse effects associated with the use of proton-pump inhibitors, comprising:

• oral administration of cholecalciferol from 10 μg and 20 μg, equivalent to 400 IU and 800 IU of vitamin D3;
• menaquinone-7 from 50 μg to 100 μg;
• methylcobalamin from 50 μg to 100 μg;
• calcium citrate malate from 1,046 mg to 2,092 mg, equivalent to 250 mg to 500 mg of elemental calcium;
• magnesium oxide from 166 mg to 664 mg, equivalent to 100 mg to 400 mg of elemental magnesium;
• ferrous bisglycinate from 90 mg to 225 mg, equivalent to 18 mg to 45 mg of elemental iron;
• Lactobacillus acidophilus from 2.5 billion CFU to 7.5 billion CFU;
• Lactobacillus casei from 2.5 billion CFU to 7.5 billion CFU;
• FOS (fructooligosaccharides) from 50 mg to 200 mg;
• and inulin from 50 mg to 200 mg.