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US 2017/0281685 A1Published application
Noble gas augmentation of regenerative cell activity
AssigneeNoblis Therapeutics, Inc.
InventorsVlad Bogin, Thomas Ichim
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AssigneeNoblis Therapeutics, Inc.
InventorsVlad Bogin, Thomas Ichim
Estimating the term…
The current invention discloses compositions of matter, therapeutic protocols, and combination therapies utilizing previously unknown activity of Xenon alone or in combination with other Noble gases to augment therapeutic activity of regenerative cells, in one embodiment said regenerative cells comprising of mesenchymal stem cells. In one embodiment the invention provides use of xenon-pretreatment of cells prior to in vivo application in order to allow for enhanced efficacy of said cells. In other embodiments xenon alone, or in combination with other gases is utilized to modulate regenerative activity of cells in vivo.
A method of generating mesenchymal stem cells with enhanced therapeutic activity, said method comprising treatment of mesenchymal stem cells with one or more Noble gases at a concentration and frequency sufficient to induce more than 5% increase in HIF-1 alpha expression in said mesenchymal stem cell.
The method of claim 6, wherein said disease condition is selected from a group comprising of:
The method of claim 65, wherein said proportion of xenon is between 22 and 60% by volume to oxygen.
The method of claim 65, wherein said proportion of xenon is between 25 and 60% by volume to oxygen.
Dependencies are inferred from the claim text.