Renal cell populations and uses thereof
AssigneeRegenMed (Cayman) Ltd.
InventorsJoydeep Basu, Kelly Guthrie, Dominic Justewicz, Teresa Burnette, Andrew Bruce, Russell W. Kelley, John W. Ludlow
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Abstract
The present invention concerns enriched heterogeneous mammalian renal cell populations characterized by biomarkers, and methods of making and using the same.
Claims19
An enriched heterogeneous mammalian renal cell population that express the biomarkers GGT-l and a cytokeratin.
A method of identifying a heterogeneous renal cell population suitable for implantation and/or eliciting a regenerative response said method comprising the steps
- Isolating cells from a mammalian kidney sample
- Exposing said isolated cells to one or more labeled detection moiety, wherein each labeled detection moiety is directed to a different biomarker and is labeled with a different label
- Determining the percentage of cells that express each of said different biomarker.
A method of treating kidney disease in a mammal comprising administering a heterogeneous renal cell population to the patient wherein the cell population expresses two or more biomarkers selected from the group consisting of GGT-1, AQP2 and a cytokeratin.
Dependencies are inferred from the claim text.