Loading patent…
AssigneesThe Government of the U.S.A. as represented by the Sec. of the Dept. of Health and Human Services, Loma Linda University, Wake Forest University
InventorsMark T. Gladwin, Alan N. Schechter, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Richard O. Cannon, III
Estimating the term…
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
A method of treating pulmonary hypertension in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a non-acidified pharmaceutically acceptable nitrite salt.
Dependencies are inferred from the claim text.