Bilayer tablets of b vitamins and process for preparing the same

A bilayer multi-B vitamin formulation comprising:

• a. a first layer comprising basic yeast and a first set of B vitamins comprising riboflavin (B2) and cyanocobalamin (B12), the first layer providing immediate release of the first set of B vitamins at a first location in the gastrointestinal tract;
• b. a second layer comprising basic yeast and a second set of B vitamins selected from the group consisting of folic acid, biotin, niacinamide (B3), pyridoxine (B6), pantothenic acid (B5), thiamine (B1), and a combination thereof, the second layer providing a modified release of the second set of B vitamins at a second location in the gastrointestinal tract;
• wherein the basic yeast from the first layer contributes to the modified release of the second set of B vitamins from the second layer;
• and
• c. optionally, a film coating that covers the first layer and the second layer.

A modified release tablet comprising:

• a. a first layer comprising basic yeast and a first set of B vitamins comprising riboflavin (B2) and cyanocobalamin (B 12), the first layer providing immediate release of the first set of B vitamins at a first location in the gastrointestinal tract;
• b. a second layer comprising basic yeast and a second set of B vitamins selected from the group consisting of folic acid, biotin, niacinamide (B3), pyridoxine (B6), pantothenic acid (B5), thiamine (B1), and a combination thereof, the second layer providing a modified release of the second set of B vitamins at a second location in the gastrointestinal tract;
• wherein the basic yeast from the first layer contributes to the modified release of the second set of B vitamins from the second layer;
• and
• c. optionally, a film coating that covers the first layer and the second layer.

A dietary supplement comprising a bilayer multi-active formulation comprising:

• a. a first layer comprising a basic yeast and a first set of active components, the first layer providing immediate release of the first set of active components at a first location in the gastrointestinal tract;
• b. a second layer comprising a basic yeast and a second set of active components, the second layer providing a modified release of the second set of active components;
• wherein the basic yeast from the first layer contributes to the modified release of the second set of the active components from the second layer at a second location in the gastrointestinal tract;
• and
• c. optionally, a film coating that covers the first layer and the second layer.