Use of thiopyrimidinecarboxamide for treating cancer
AssigneeSyntrix Biosystems, Inc.
InventorsJohn A. Zebala, Dean Y. Maeda, Aaron D. Schuler
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Abstract
There is disclosed is a method of treating disease using compound having formula SX-682 alone or in combination with an antineoplastic agent, microtubule affecting agents, antineoplastic agents, anti-angiogenesis agents, VEGF receptor kinase inhibitors, antibodies against the VEGF receptor, interferon, or radiation.
Claims20
A method for treating a CXCR1/2 chemokine mediated disease in a patient in need of such treatment, comprising administering an effective amount of the compound having formula SX-682
- or a pharmaceutically acceptable salt or solvate thereof, wherein the patient has atopic dermatitis, asthma, inflammatory bowel disease, Crohn's disease, ulcerative colitis, Alzheimer's disease, atherosclerosis, cerebral ischemia, cardiac ischemia, multiple sclerosis, cystic fibrosis, psoriatic arthritis, tumors dependent on angiogenesis for growth, pancreatitis, alcoholic hepatitis, or alcoholic liver disease.
A method for treating a transplant patient in need of such treatment, comprising administering an effective amount of the compound having formula SX-682
- or a pharmaceutically acceptable salt or solvate thereof, wherein the patient has graft vs. host reaction, allograft rejections, transplant reperfusion injury, early transplantation rejection, or renal reperfusion injury.
A method for treating pain in a patient in need of such treatment, comprising administering an effective amount of the compound having formula SX-682
- or a pharmaceutically acceptable salt or solvate thereof, wherein the patient has acute inflammatory pain, chronic inflammatory pain, or neuropathic pain.
A pharmaceutical formulation comprising a therapeutically effective amount of the compound having formula SX-682
- or a pharmaceutically acceptable salt or solvate thereof, and a self-emulsifying drug delivery system.
Dependencies are inferred from the claim text.