Low Osmolality Gel Composition
AssigneeImQuest BioSciences, Inc.
InventorsRobert W. Buckheit, JR., Anthony Sang Won Ham
Life of this patent
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Abstract
The present invention relates to polymer gel compositions and more specifically to polymer gel compositions having low osmolality for use on rectal mucosa. The present invention extends to their methods of manufacture and use, including as drug delivery vehicles and personal lubricants.
Claims26
A personal lubricant composition comprising at least one water soluble polyhydric alcohol and at least one water-soluble polymer derived from cellulose, wherein the personal lubricant has an osmolality between about 200 mOsm/kg and about 500 mOsm/kg and a pH of about 7 or less.
A microbicide composition comprising at least one water-soluble polyhydric alcohol, at least one water-soluble polymer derived from cellulose and at least one antimicrobial agent, wherein the microbicide composition has an osmolality between about 200 mOsm/kg and about 500 mOsm/kg and a pH of about 7 or less.
A rectal drug delivery vehicle comprising at least one water-soluble polyhydric alcohol, a water-soluble polymer derived from cellulose and at least one antimicrobial agent, wherein the drug delivery vehicle has an osmolality between about 200 mOsm/kg and about 500 mOsm/kg and a pH of about 7 or less.
A method of manufacturing a composition, comprising the steps of:
- a) preparing an aqueous buffered solution and separating into a first and second portion,
- b) combining polyhydric alcohol and preservatives in a vial, heating to dissolution and cooling to room temperature,
- c) adding the mixture from step (ii) to the first portion of buffered solution while stirring,
- d) adding a volume of the second portion of buffered solution to the vial from step (d), mixing and adding the volume to the stirring first portion of the buffered solution and repeating step (iv) with all of the second portion of buffered solution
- e) gradually adding water-soluble cellulosic polymer to buffered solution and continue stirring until homogeneous, and
- f) adjusting pH to about 5.0 to 7.0.
Dependencies are inferred from the claim text.