Steroid hormone compositions in medium chain oils
OwnerAnnette Shadiack, Peter H.R. Persicaner +4inventors
InventorsANNETTE SHADIACK, PETER H.R. PERSICANER, PHILIP B. INSKEEP, THORSTEINN THORSTEINSSON, FREDERICK D. SANCILIO, JASON D. LEGASSIE
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Abstract
This disclosure provides a novel pharmaceutical composition capable of forming micelles upon exposure to the gastric environment. The pharmaceutical composition is suitable for delivering steroid hormones, and the combination of estradiol and progesterone in particular, to a subject in need thereof.
Claims28
A pharmaceutical composition for providing enhanced oral bioavailability of estradiol and/or progesterone, the pharmaceutical composition comprising:
- estradiol, progesterone, a polysorbate, and a medium chain oil, wherein the medium chain oil comprises at least about 50 weight percent of a predominantly medium chain monoglyceride;
- and
- the estradiol and the progesterone are both fully solubilized.
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An oral, fully-solubilized estradiol and progesterone pharmaceutical composition comprising:
- estradiol, progesterone and a polysorbate in a weight ratio of from about 1:2 to about 2:1;
- and
- a medium chain oil comprising a mixture of medium chain mono- and diglycerides, the medium chain oil not containing more than about 10 weight percent triglycerides.
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A pharmaceutical composition for providing enhanced oral bioavailability of estradiol and/or progesterone, the pharmaceutical composition comprising:
- estradiol, progesterone, a polysorbate, and a medium chain oil, wherein the medium chain oil comprises at least about 50 weight percent of a first medium chain oil component;
- and
- the estradiol and progesterone are both fully solubilized.
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Dependencies are inferred from the claim text.