Formulations of testosterone and methods of treatment therewith
AssigneesBoard of Regents, The University of Texas System, Medcara Pharmaceuticals, LLC
InventorsRobert A. JOSEPHS, Craig HERMAN
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Abstract
The present disclosure relates to novel pharmaceutical composition for the administration of testosterone or testosterone derivatives. The present disclosure also provides methods of treatment of diseases and disorders associated with fear and anxiety, a decrease in libido, or hypogonadism.
Claims100
A pharmaceutical composition comprising the following components dissolved in an aqueous solution:
- (A) a compound of the formula:
- wherein:
- R1 is hydrogen, acyl(C≦12), or substituted acyl(C≦12);
- (B) a first additive substantially comprised of a compound of the formula:
- wherein:
- R2, R3, and R4 are each independently selected from alkyl(C≦12),
- alkenyl(C≦12), alkynyl(C≦12), or a substituted version of any of these groups;
- and
- (C) a second additive substantially comprised of a compound of the formula:
- wherein:
- x, y, z, a, b, and c are each independently a number selected from 0-40 provided that at least one of x, y, z, a, b, or c is not 0;
- and
- m and n are each independently selected from 0, 1, or 2.
A pharmaceutical composition comprising a testosterone ester(C≦12), water, and a first additive.
A pharmaceutical composition comprising about 1.2% by weight testosterone propionate, about 69.8% by weight distilled water, about 5.0% by weight Neobee® M-5, and about 24% by weight Cremophor® EL.
A pharmaceutical composition comprising about 2.2% by weight testosterone propionate, about 58.7% by weight distilled water, about 14.3% by weight Neobee® M-5, and about 24.8% by weight Cremophor® EL.
A method of treating a disease or disorder in a patient in need thereof comprising nasally administering to the patient a therapeutically effective amount of testosterone.
Dependencies are inferred from the claim text.