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US 2017/0281637 A1Published application
Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors
AssigneeKudos Pharmaceuticals Limited
InventorsHeather Mary Ellen Duggan, Frederic Georges Marie Leroux, Karine Fabienne Malagu, Niall Morrison Barr Martin, Keith Menear, Graeme Cameron Murray Smith
Life of this patent
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Abstract
There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
Claims39
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- one or two of X5, X6 and X8 is N, and the others are CH;
- R7 is selected from halo, ORO1, SRS1, NRN1RN2, NRN7aC(O)RC1, NRN7bSO2RS2a, an optionally substituted 5- to 20-membered heteroaryl group, or an optionally substituted C5-20 aryl group,
- where RO1 and RS1 are selected from H, an optionally substituted C5-20 aryl group, an optionally substituted 5- to 20-membered heteroaryl group, or an optionally substituted C1-7 alkyl group;
- RN1 and RN2 are independently selected from H, an optionally substituted C1-7 alkyl group, an optionally substituted 5- to 20-membered heteroaryl group, an optionally substituted C5-20 aryl group or RN1 and RN2 together with the nitrogen to which they are bound form an optionally substituted heterocyclic ring containing between 3 and 8 ring atoms;
- RC1 is selected from H, an optionally substituted C5-20 aryl group, an optionally substituted 5- to 20-membered heteroaryl group, an optionally substituted C1-7 alkyl group or NRN8RN9, where RN8 and RN9 are independently selected from H, an optionally substituted C1-7 alkyl group, an optionally substituted 5- to 20-membered heteroaryl group, an optionally substituted C5-20 aryl group or RN8 and RN9 together with the nitrogen to which they are bound form an optionally substituted heterocyclic ring containing between 3 and 8 ring atoms;
- RS2a is selected from H, an optionally substituted C5-20 aryl group, an optionally substituted 5- to 20-membered heteroaryl group, or an optionally substituted C1-7 alkyl group;
- RN7a and RN7b are selected from H and a C1-4 alkyl group;
- R2 is selected from H, halo, ORO2, SRS2b, NRN6RN6, an optionally substituted 5- to 20-membered heteroaryl group, and an optionally substituted C5-20 aryl group,
- wherein RO2 and RS2b are selected from H, an optionally substituted C5-20 aryl group, an optionally substituted 5- to 20-membered heteroaryl group, or an optionally substituted C1-7 alkyl group;
- RN5 and RN6 are independently selected from H, an optionally substituted C1-7 alkyl group, an optionally substituted 5- to 20-membered heteroaryl group, and an optionally substituted C5-20 aryl group, or RN5 and RN6 together with the nitrogen to which they are bound form an optionally substituted heterocyclic ring containing between 3 and 8 ring atoms.
8 more elements
Dependencies are inferred from the claim text.