Derivatives of macrocyclic n-aryl-2-amino-4-aryl-pyrimidine polyethers as inhibitors of ftl3 and jak

A compound of the following general formula (I):

• or a pharmaceutically acceptable salt and/or solvate thereof,
• wherein:
• W represents an oxygen or sulfur atom,
• Y represents a nitrogen atom or a CRy group wherein Ry represents a hydrogen atom, a halogen atom, a (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, OH, CN, NO2, NR12R13, CO2H or CO2((C1-C6)alkyl) group,
• Z represents a (CRQ1RQ2)nQ(CRQ3RQ4)m group, wherein n and m represent, independently of each other, an integer between 0 and 3,
• Q represents O, S, S(O) or S(O)2,
• RQ1, RQ2, RQ3 and RQ4 represent, independently of each other, a hydrogen atom or a (C1-C6)alkyl group,
• R1, R2, R1′ and R2′ represent, independently of each other, a hydrogen atom or a (C1-C6)alkyl group,
• R3, R4, R3′ and R4′ represent, independently of each other, a hydrogen atom, a (C1-C6)alkyl or OH group or R3 and R4 and/or R3′ and R4′ together form, with the carbon atom that bears them, an optionally substituted monocyclic carbocycle or heterocycle,
• R5 and R6 represent, independently of each other, a hydrogen atom, a halogen atom, a (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, (C1-C6)thioalkoxy, (C 1-C6)halothioalkoxy, OH, SH, CN, NO2, or NR7R8 group,
• R9 and R10 represent, independently of each other, a hydrogen atom, a halogen atom, an optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkoxy, optionally substituted (C1-C6)thioalkoxy, CN, NO2, OH, SH, NR14R15, CO2R54, CONR55R56 group, an optionally substituted carbocycle or an optionally substituted heterocycle,
• R11 represents a hydrogen atom, a halogen atom, or a (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy or (C1-C6)haloalkoxy group, and
• R7, R8, R12, R13, R14, R15, R54, R55 and R56 represent, independently of each other, a hydrogen atom or an optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, or optionally substituted (C2-C6)alkynyl group, or R7 and R8, R12 and R13, R14 and R15 and/or R55 and R56, independently of each other, form with the nitrogen atom that bears them an optionally substituted nitrogen containing heterocycle.