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US 2017/0281614 A1Published application
Certain chemical entities, compositions and methods
AssigneeIntellikine LLC
InventorsPingda Ren, Yi Liu, Troy Edward Wilson, Liansheng Li, Katrina Chan, Christian Rommel
Life of this patent
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Abstract
Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.
Claims20
1-22. (canceled)
A process for preparing a compound of formula:
- or a pharmaceutically acceptable salt thereof, wherein
- R3 is halo;
- comprising deprotecting a compound of formula:
- wherein the deprotection occurs in the presence of an acid.
1 more element
A compound of Formula V-A2:
- or its pharmaceutically acceptable salt thereof, wherein
- B is a moiety of Formula II:
- wherein Wc is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl;
- q is an integer of 0, 1, 2, 3, or 4;
- R1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amido, alkoxycarbonyl, sulfonamido, halo, cyano, or nitro;
- R2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl, alkoxy, amino, halo, cyano, hydroxy or nitro;
- R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, alkoxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, aryl or heteroaryl;
- and
- each instance of R9 is independently hydrogen, alkyl, or heterocycloalkyl.
6 more elements
Dependencies are inferred from the claim text.