Methods for the Treatment of Cystic Fibrosis

A method of treating or lessening the severity of CF, comprising the step of administering to a patient in need an effective amount of

• i) a GSNOR inhibitor of Formula I
• wherein
• m is selected from the group consisting of 0, 1, 2, and 3;
• R1 is independently selected from the group consisting of chloro, fluoro, bromo, cyano, and methoxy;
• R2b and R2c are independently selected from the group consisting of hydrogen, halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and N(CH3)2;
• X is selected from the group consisting of
• n is selected from the group consisting of 0, 1, and 2;
• R3 is independently selected from the group consisting of halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and NR4R4′ where R4 and R4′ are independently selected from the group consisting of C1-C3 alkyl, or R4 when taken together with R4′ form a ring with 3 to 6 members;
• and
• A is selected from the group consisting of
• or a pharmaceutically acceptable salt thereof, and
• ii) one or more secondary active agents selected from the group consisting of CFTR correctors and CFTR potentiators or pharmaceutically acceptable salt(s) thereof.