Pharmaceutical compositions and methods for the treatment of diabetes
AssigneeUniversity of Limerick
InventorMark Davies
Life of this patent
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Abstract
This invention relates to compositions and methods for treating type I diabetes. Compositions of the invention include active compounds such as harmine, INDY, or derivatives thereof to induce reproduction of beta cells. These active compounds are provided in amounts that have poor clinical efficacy on their own, but when administered at a sub-threshold dose in combination with compounds such as insulin, which helps to maintain steady levels of insulin in the body; metformin, which decreases glucose levels; and repaglinide, which increases insulin production, allow for the slow and steady increase of beta cells.
Claims20
A pharmaceutical composition comprising:
- harmine in an amount insufficient to stimulate pancreatic beta cell production if administered alone in a single dose;
- and
- a pharmaceutically-acceptable excipient.
A pharmaceutical composition comprising:
- harmine or INDY in an amount that would be insufficient to stimulate pancreatic beta cell production in a single administration to a patient when the concentration of harmine in the patient is zero.
A pharmaceutical composition comprising:
- harmine in an amount insufficient to cause psychotoxic effects;
- one or more compounds selected from the group consisting of insulin or an analog thereof, metformin, and repaglinide;
- and
- a pharmaceutically-acceptable excipient.
Dependencies are inferred from the claim text.