Solid forms of (s)-2-methoxy-3--propionic acid and of salts thereof
AssigneeHoffmann-La Roche Inc.
InventorsLukas Dreier, Andre Egli, Karsten Faehnrich, Olaf Grassmann, Peter Mohr, Urs Schwitter, Helmut Stahr, Nicole Wyttenbach
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Abstract
The present invention relates to solid forms of (S)-2-methoxy-3-{442-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxyl-benzo[b]thiophen-7-yl}-propionic acid, and of salts of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid.
Claims18
A solid form of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid characterized by an X-ray powder diffraction pattern obtained with a Cu Kα radiation having characteristic peaks expressed in degrees 2Theta at approximately 4.9, 8.1, 11.8, 13.2, 13.9, 14.9, 18.5, 21.0, 21.6, 22.7, 25.3, 26.2 and 28.5.
A solid form of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid characterized by an X-ray powder diffraction pattern obtained with a Cu Kα radiation having characteristic peaks expressed in degrees 2Theta at approximately 5.0, 8.1, 12.0, 13.0, 13.7, 14.9, 18.9, 21.3, 24.2 and 26.3.
A solid form of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid characterized by an X-ray powder diffraction pattern obtained with a Cu Kα radiation having characteristic peaks expressed in degrees 2Theta at approximately 5.0, 8.0, 8.3, 12.8, 13.6, 14.0, 16.7, 21.0 and 23.0.
A solid form of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid characterized by a Raman spectrum having sharp bands at 3073, 2927, 1648, 1608, 1576, 1556, 1511, 1453, 1399, 1352, 1326, 1237, 1176, 1003, 975, 951, 682, 618 and 438 cm−1 (±3 cm−1).
A solid form of sodium (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propanoate characterized by an X-ray powder diffraction pattern obtained with a Cu Kα radiation having characteristic peaks expressed in degrees 2Theta at approximately 4.7, 4.8, 5.3, 7.9, 8.8, 13.1, 13.5, 13.8, 14.1, 14.5, 17.6, 19.3, 19.9, 21.6, 23.1 and 23.4.
A solid form of sodium (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propanoate characterized by an X-ray powder diffraction pattern obtained with a Cu Kα radiation having characteristic peaks expressed in degrees 2Theta at approximately 4.7, 8.2 and 9.5.
A solid form of sodium (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propanoate characterized by a Raman spectrum having sharp bands at 3072, 2926, 1643, 1608, 1572, 1556, 1510, 1451, 1387, 1350, 1233, 1174, 1025, 1003, 951, 845, 683, 617 and 444 cm−1 (±3 cm−1).
A solid form of diisopropylammonium (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-y1)-ethoxy]-benzo[b]thiophen-7-yl}-propanoate characterized by an X-ray powder diffraction pattern obtained with a Cu Kα radiation having characteristic peaks expressed in degrees 2Theta at approximately 6.3, 7.9, 10.2, 11.9, 12.7, 13.3, 13.8, 17.6, 18.6, 22.1, 23.6, 24.0, 24.4, 26.8, 27.1 and 29.5.
Dependencies are inferred from the claim text.