Methods and compositions for treating clostridium difficile associated disease

A method of treating a Clostridium difficile (C. diff.) infection in a subject, the method comprising:

• administering to the subject a) an effective amount of one or more antibiotics effective against C. diff, b) an immunoglobulin concentrate (IgC), and c) a low protein diet for a time period sufficient to reduce, attenuate, or inhibit the effects of of the C. diff infection;
• wherein the IgC comprises gamma-globulin isolated from an animal source selected from serum, plasma, egg, or milk;
• wherein the IgC comprises at least 40% IgC by weight;
• and wherein the low protein diet provides ≦75% of the subject's daily protein requirement.