Solid molecular dispersion of fesoterodine hydrogen fumarate and polymeric binder
AssigneePfizer Inc.
InventorsRoland Bodmeier, Alan Francis Carmody, Mesut Ciper, Anne Therese Gustaaf De Paepe, John Mark Heimlich, Martin Korber, Mathias Walther, Neil Feeder
Life of this patent
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Abstract
The present invention relates to solid molecular dispersion of fesoterodine hydrogen fumarate and a polymeric binder. The invention also relates to an inert core bead or particle which is coated with said solid molecular dispersion and to pharmaceutical formulations comprising such coated beads or particles.
Claims25
A solid molecular dispersion comprising from 3:97 to 12:88 weight % ratio of fesoterodine hydrogen fumarate:an alkyl hydroxyalkylcellulose ether or a hydroxyalkylcellulose ether, or an ester of either thereof, or a mixture of any two or more thereof.
A solid dispersion comprising from 3:97 to 12:88 weight % ratio of fesoterodine hydrogen fumarate:an alkyl hydroxyalkylcellulose ether or a hydroxyalkylcellulose ether, or an ester of either thereof, or a mixture of any two or more thereof, in which the fesoterodine hydrogen fumarate is stabilised in the dispersion in a form not corresponding to its crystalline or amorphous form.
A solid dispersion comprising from 3:97 to 12:88 weight % ratio of fesoterodine hydrogen fumarate:an alkyl hydroxyalkylcellulose ether or a hydroxyalkylcellulose ether, or an ester of either thereof, or a mixture of any two or more thereof, in which the fesoterodine hydrogen fumarate is stabilised in the dispersion in a form not corresponding to its crystalline or amorphous form and which generally displays the FTIR characteristics shown in FIG. 3, 3a, 4, 4a, 5, 5a, 7, 7a, 8 or 8a.
A solid molecular dispersion obtainable by (a) achieving a solution of fesoterodine hydrogen fumarate and an alkyl hydroxyalkylcellulose ether or a hydroxyalkylcellulose ether, or an ester of either thereof, or a mixture of any two or more thereof, in from 3:97 to 12:88 weight % ratio, and (b) by drying to form said dispersion.
Dependencies are inferred from the claim text.