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US 2017/0281583 A1Published application
Methods for treating brain injury
AssigneesHough Ear Institute, Oklahoma Medical Research Foundation
InventorsRichard D. KOPKE, Robert A. FLOYD, Rheal TOWNER
Life of this patent
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Abstract
The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl α-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).
Claims10
1-10. (canceled)
A method for increasing the bioavailability of a compound in the central nervous system, the method comprising the steps of:
- administering 2,4-disulfonyl a-phenyl tertiary butyl nitrone to an organism in an amount sufficient to increase blood-brain barrier permeability;
- and
- administering the compound to the organism either concurrently or following administration of 2,4-disulfonyl a-phenyl tertiary butyl nitrone.
Dependencies are inferred from the claim text.