Back to results
US 2017/0281570 A1Published application
Topical and transdermal delivery of hif-1 modulators to prevent and treat chronic wounds
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsGeoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou
Life of this patent
Estimating the term…
Abstract
Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1α in the wound.
Claims8
A method to treat a chronic skin wound on an individual at risk for chronic wounds, the method comprising:
- contacting skin topically with a transdermal patch comprising:
- a film comprising deferoxamine (DFO) at a concentration of from at least about 1% and not more than about 20% as weight/weight percent of film, encapsulated in a reverse micelle with polysorbate 80 and sorbitan monolaurate 20 at a concentration of from about 5 weight % to about 25 weight %, which reverse micelle is stabilized by polyvinylpyrrolidine (PVP) in an ethylcellulose matrix, wherein the film is adhered to an impermeable backing membrane;
- wherein the DFO penetrates stratum corneum to release in underlying dermal tissues of the skin.
A method to prevent a skin ulcer on an individual at risk for chronic wounds, the method comprising:
- contacting skin susceptible to ulcer formation topically with a transdermal patch comprising:
- a film comprising deferoxamine (DFO) at a concentration of from at least about 1% and not more than about 20% as weight/weight percent of film, encapsulated in a reverse micelle with polysorbate 80 and sorbitan monolaurate 20 at a concentration of from about 5 weight % to about 25 weight %, which reverse micelle is stabilized by polyvinylpyrrolidine (PVP) in an ethylcellulose matrix, wherein the film is adhered to an impermeable backing membrane;
- and
- wherein the DFO penetrates stratum corneum to release in underlying dermal tissues of the skin.
1 more element
Dependencies are inferred from the claim text.