Oral pharmaceutical formulation in the form of an aqueous suspension of microcapsules for the modified release of active principle(s).

Suspension of microcapsules in an aqueous liquid phase that allows the modified release of at least one active principle (excluding amoxicillin) and is intended for oral administration, characterized in that:

• it comprises a plurality of microcapsules each consisting of a core containing at least one active principle (excluding amoxicillin) and of a film coating that:
• is applied to the core,
• controls the modified release of the active principle(s),
• and has a composition corresponding to one of the following three families A, B and C:
• Family A
• 1A—at least one film-forming polymer (P1) insoluble in the tract fluids, present in an amount of 50 to 90 and preferably of 50 to 80% by dry weight, based on the total weight of the coating composition, and consisting of at least one water-insoluble cellulose derivative;
• 2A—at least one nitrogen-containing polymer (P2) present in an amount of 2 to 25 and preferably of 5 to 15% by dry weight, based on the total weight of the coating composition, and consisting of at least one polyacrylamide and/or poly-N-vinylamide and/or poly-N-vinyllactam;
• 3A—at least one plasticizer present in an amount of 2 to 20 and preferably of 4 to 15% by dry weight, based on the total weight of the coating composition, and consisting of at least one of the following compounds:
• glycerol esters, phthalates, citrates, sebacates, cetyl alcohol esters and castor oil;
• 4A—at least one surfactant and/or lubricant present in an amount of 2 to 20 and preferably of 4 to 15% by dry weight, based on the total weight of the coating composition, and selected from anionic surfactants and/or non-ionic surfactants and/or lubricants, it being possible for said agent to comprise only one or a mixture of the above-mentioned products;
• Family B
• 1B—at least one hydrophilic polymer carrying groups ionized at neutral pH and preferably selected from cellulose derivatives;
• 2B—at least one hydrophobic compound different from A;
• Family C
• 1C—at least one film-forming polymer insoluble in the gastrointestinal tract fluids;
• 2C—at least one water-soluble polymer;
• 3C—at least one plasticizer;
• 4C—optionally at least one surfactant/lubricant preferably selected from the following group of products:
• anionic surfactants;
• and/or non-ionic surfactants,
• and the liquid phase is saturated or becomes saturated with active principle(s) on contact with the microcapsules.