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US 2017/0281537 A1Published application
Lipid formulations comprising a thiolated antioxidant
AssigneeCamurus AB
InventorsCatalin NISTOR, Fredrik TIBERG, Krister THURESSON, Markus JOHNSSON
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Abstract
The present invention provides a formulation comprising a lipid matrix; at least one thiolated antioxidant; at least one bioactive agent; and optionally at least one chelating agent. The bioactive agent may be a gonadotrophin-releasing hormone (GnRH) agonist; a gonadotrophin-releasing hormone (GnRH) antagonist; a luthenizing hormone releasing hormone (LHRH); and/or a luthenizing hormone releasing hormone (LHRH) related peptide.
Claims11
1) A formulation comprising:
- i) a lipid matrix;
- ii) at least one thiolated antioxidant;
- iii) at least one of:
- a gonadotrophin-releasing hormone (GnRH) agonist;
- a gonadotrophin-releasing hormone (GnRH) antagonist;
- a luthenizing hormone releasing hormone (LHRH);
- and/or
- a luthenizing hormone releasing hormone (LHRH) related peptide;
- and
- iv) optionally at least one chelating agent.
7 more elements
10) A method for reducing oxidative degradation in a formulation comprising a lipid matrix and at least one of:
- a gonadotrophin-releasing hormone (GnRH) agonist;
- a gonadotrophin-releasing hormone (GnRH) antagonist;
- luthenizing hormone releasing hormone (LHRH);
- and/or
- a luthenizing hormone releasing hormone (LHRH) related peptide;
- said method comprising adding at least one thiolated antioxidant and optionally at least one chelating agent to the formulation.
3 more elements
Dependencies are inferred from the claim text.