Administration of intravenous ibuprofen

A method for reducing surgical pain in human patients, consisting of

• (i) treating post-surgical pain by administering a first dose of intravenous ibuprofen solution in an amount of about 800 mg prior to the start of surgery on the patients,
• (ii) intravenously administering a further dose of about 800 mg dose of intravenous ibuprofen about every six hours post-operatively to the patients at least until 24 hours after surgery and about every 6 hours from about 24 hours after surgery up to about 5 days after surgery;
• and
• (iii) administering an opioid analgesic(s) post-operatively to the patients in an amount which is reduced by about 20% or more within the first 24 hours after surgery than that typically required to control pain in human patients having undergone the same surgical procedure without said administration of ibuprofen, such that the human patients receiving intravenous ibuprofen experience about a 30% reduction in mean opioid consumption and also experience a reduction in post-operative pain of from about 15 to about 42% as measured by the VAS with movement and at rest area under the curve.

A method for reducing surgical pain in human patients, comprising

• (i) treating post-surgical pain by administering a first dose of intravenous ibuprofen solution in an amount of about 800 mg prior to the start of surgery on the patients,
• (ii) intravenously administering a further dose of about 800 mg dose of intravenous ibuprofen about every six hours post-operatively to the patients at least until 24 hours after surgery and about every 6 hours from about 24 hours after surgery up to about 5 days after surgery;
• and
• (iii) administering an opioid analgesic(s) post-operatively to the patients in an amount which is reduced by about 20% or more within the first 24 hours after surgery than that typically required to control pain in human patients having undergone the same surgical procedure without said administration of ibuprofen such that the patients experience a reduction in post-operative pain of from about 15 to about 42% as measured by the VAS with movement and at rest area under the curve.

A method for reducing surgical pain in human patients, consisting of

• (i) treating post-surgical pain by administering a first dose of intravenous ibuprofen solution in an amount of about 800 mg prior to the start of surgery on the patients,
• (ii) intravenously administering a further dose of about 800 mg dose of intravenous ibuprofen about every six hours post-operatively to the patients at least until 24 hours after surgery and about every 6 hours from about 24 hours after surgery up to about 5 days after surgery;
• and
• (iii) administering an opioid analgesic(s) post-operatively to the patients in an amount such that the human patients receiving intravenous ibuprofen experience about a 30% reduction in mean opioid consumption and experience a reduction in post-operative pain of from about 15 to about 42% as measured by the VAS with movement and at rest area under the curve compared to the amount of opioid analgesic(s) typically required to control pain in human patients having undergone the same surgical procedure without said administration of the ibuprofen.