System and method for monitoring nitric oxide levels using a non-invasive, multi-band biosensor
AssigneeSanmina Corporation
InventorRobert Steven Newberry
Life of this patent
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Abstract
A biosensor includes a PPG circuit that emits light directed at living tissue at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength and a second wavelength. Using absorption coefficients for substances at the plurality of wavelengths, concentration levels of a plurality of substances such as Nitric Oxide may then be determined from the spectral responses.
Claims20
A biosensor for monitoring nitric oxide (NO) of a patient in vivo, comprising:
- a PPG circuit configured to:
- generate at least a first spectral response for light reflected around a first wavelength from skin tissue of the patient;
- generate at least a second spectral response for light reflected around a second wavelength from the skin tissue of the patient;
- a processing circuit configured to:
- obtain a value Lλ1 using the first spectral response, wherein the value Lλ1 isolates the first spectral response due to pulsating arterial blood flow;
- obtain a value Lλ2 using the second spectral response, wherein the value Lλ2 isolates the second spectral response due to pulsating arterial blood flow;
- obtain a value Rλ1, λ2 from a ratio of the value Lλ1 and the value Lλ2;
- and
- obtain a concentration level of nitric oxide using the value Rλ1, λ2 and a calibration database, wherein the calibration database is used to correlate the value Rλ1, λ2 and the concentration level of nitric oxide (NO).
A biosensor for monitoring nitric oxide (NO) of a patient in vivo, comprising:
- a PPG circuit configured to:
- generate at least one spectral response from light reflected around a range of wavelengths from skin tissue of the patient;
- a processing circuit configured to:
- determine an absorbance spectra curve for hemoglobin from the spectral response;
- determine a degree of shift of the absorbance spectra curve of hemoglobin due at least to a presence of NO;
- access a calibration database that include correlations of degrees of shifts of the absorbance spectra to concentration levels of nitric oxide (NO);
- and
- obtain a concentration level of nitric oxide using the calibration database.
A method for monitoring nitric oxide (NO) of a patient in vivo, comprising:
- obtaining at least a first spectral response for light reflected around a first wavelength from skin tissue of the patient;
- obtaining at least a second spectral response for light reflected around a second wavelength from the skin tissue of the patient;
- obtaining a value Lλ1 using the first spectral response, wherein the value Lλ1 isolates the first spectral response due to pulsating arterial blood flow;
- obtaining a value Lλ2 using the second spectral response, wherein the value Lλ2 isolates the second spectral response due to pulsating arterial blood flow;
- obtaining a value Rλ1, λ2 from a ratio of the value Lλ1 and the value Lλ2;
- and
- obtaining a concentration level of nitric oxide using the value Rλ1, λ2 and a calibration database, wherein the calibration database correlates the value Rλ1, λ2 and the concentration level of nitric oxide (NO).
Dependencies are inferred from the claim text.