Methods and devices for analyte sensing in potential spaces
AssigneeTheraNova, LLC
InventorsDaniel R. BURNETT, Evan S. LUXON
Life of this patent
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Abstract
Use of the peritoneal space provides a more direct tracking of blood glucose, capturing faster glucose kinetics, avoiding membrane/encapsulation effects, having less lag time and lag time variability, and eliminating the effect of variations in skin temperature, cardiac output, and body position during sleep. A peritoneal sensor system may be implanted within the peritoneal space and may generally include a sensor/sampler portion, which is implanted in the peritoneal space, and a control portion/controller, which may be implanted elsewhere, such as subcutaneously, or may be external to the patient.
Claims57
A peritoneal fluid sensing apparatus comprising:
- a catheter having a distal tip which is tapered;
- a sensor positioned within the tapered distal tip of the catheter, wherein the sensor is configured to sense for a presence of one or more analytes when positioned within peritoneal fluid of a subject;
- a filter in fluid communication with the sensor, wherein the filter is permeable to the one or more analytes;
- a controller in communication with the sensor;
- and
- a port in fluid communication with the catheter and the sensor, infusion of a fluid through the port flushes the sensor with the fluid.
A peritoneal fluid sensing apparatus, comprising:
- a catheter having a distal tip which is tapered;
- a sensor configured to sense for a presence of one or more analytes when contacting peritoneal fluid of a subject;
- a controller in communication with the sensor, wherein the sensor is positioned within the controller;
- a filter in fluid communication with the sensor, wherein die filter is permeable to the one or more analytes;
- and
- a port in fluid communication with the catheter and the sensor, wherein infusion of a fluid through the port flushes the filter with the fluid.
A method of detecting one or more analytes within a subject, comprising:
- contacting peritoneal fluid within the subject via a distal tip of a catheter, where the distal tip is tapered to inhibit or reduce an ability of a fibrotic capsule from obtaining purchase;
- filtering the peritoneal fluid, wherein the filter is permeable to the one or more analytes;
- sensing for a presence of one or more analytes within the peritoneal fluid via a sensor;
- determining whether the one or more analytes are present within the peritoneal fluid via a controller in communication with the sensor;
- and
- infusing a fluid within the catheter such the fluid flushes the distal tip.
Dependencies are inferred from the claim text.