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US 2017/0280984 A1Published application
Polymer-type fluorescent molecule probe
AssigneeHiroshi Maeda
InventorsHiroshi MAEDA, Makoto HASHIZUME, Jun FANG, Hideaki NAKAMURA, Haibo QIN, Steffen HACKBARTH, Masaharu MURATA
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Abstract
The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatible macromolecule.
Claims10
1-13. (canceled)
A complex comprising a fluorescent molecule and a biocompatible macromolecule,
- wherein the fluorescent molecule is selected from rose bengal, indocyaninegreen, Zn bound phthalocyanidine, porphyrins with the proviso that the porphyrins do not include protoporphyrins, Zn bound pheophorbide, methylene blue, Zn bound foscan, Zn orthophenanthroline, Cu phenanthroline, acriflavine, acrinol, acridine diamine, acridine, acridine orange, tetracycline, aminofluorescein, tetramethylrhodamine, aminorhodamine, dichlorofluorescein, and mixtures thereof, and
- the biocompatible macromolecule selected from styrene-maleic acid copolymers, styrene-maleic acid copolymers having a multiple-functionalized maleic acid side chain,
- hydroxylpropylmetaacrylamide copolymers, serum albumin, transferrin, immunoglobulin, α1-acidglycoprotein, α1-antitrypsin, solubilized gelatin, polyvinyl alcohol, polyvinyl pyrolidone, and mixtures thereof.
Dependencies are inferred from the claim text.