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AssigneesTrustees of Boston University, Massachusetts Institute of Technology
InventorsJames J. Collins, Timothy Kuan-Ta Lu
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Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in these biological converter switches is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a variety of network topologies to create circuits that act, for example, as switchboards, and regulate the production of an output product(s) based on the combination and nature of input signals received.
A digital-to-analog biological converter switch, the digital-to-analog biological converter switch comprising at least two single invertase memory modules (SIMM), wherein each SIMM comprises at least one module comprising an inducible promoter sequence (iP), a forward recombinase recognition site sequence (RRSfor), an inverted promoter sequence (Pinv), a recombinase gene sequence (RC), a reverse recombinase recognition site sequence (RRSrev), an inverted second inducible promoter sequence (iPinv, 2), and an output product sequence (OP), (iP-RRSfor-Pinv-RC-RRSrev-iPinv, 2-OP)n;
Dependencies are inferred from the claim text.