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US 2017/0254818 A1Published application
Cns-specific biomarkers for cns diseases or injuries
AssigneeThe Board of Regents of the University of Texas Sy Stem
InventorsWilliam E. HASKINS, Thomas G. FORSTHUBER
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Abstract
Methods and compositions for detecting and/or measuring biomarkers associated with compromised BBB.
Claims11
A method of evaluating a patient suspected of having a central nervous system (CNS) disease comprising:
- measuring the level of at least one protein biomarker or peptide biomarker selected from SEQ ID NO:1 to SEQ ID NO:544 in a biologic sample from the patient, wherein the patient is suspected of having, is at risk of developing, or has been diagnosed with a CNS disease;
- classifying the subject based on the levels of at least one biomarker associated with a CNS disease or a CNS injury.
A method of detecting a preclinical expression wave comprising measuring biomarker levels in two or more samples from a patient that were obtained at different times and determining the rate of change of biomarker expression.
Dependencies are inferred from the claim text.