Method and devices for capturing circulating tumor
AssigneeThe Board of Trustees of the University of Illinois
InventorsSeungpyo Hong, Ja Hye Myung, David Eddington, Cari Launiere
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Abstract
A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device.
Claims21
A method of capturing a Circulating Tumor Cell (CTC) from a sample comprising the step of introducing said sample into a microfluidic device under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent, the device inducing a rotational flow with the sample, the device comprising an immobilized cell rolling-inducing agent and an immobilized capturing agent.
(canceled)
13-22. (canceled)
A microfluidic device for capturing a Circulating Tumor Cell (CTC) from a sample, comprising:
- a channel comprising a cell capture surface and a flow modification surface,
- wherein the cell capture surface comprises a cell rolling-inducing agent and a capturing agent immobilized on the cell capture surface, and
- the flow modification surface comprises one or more ridges extending into the channel and arranged to induce a rotational flow in a sample flowing through the channel.
(canceled)
30-56. (canceled)
Dependencies are inferred from the claim text.