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AssigneeHoffmann-La Roche Inc.
InventorsChristian Klein, Ekkehard Moessner, Ralf Hosse, Peter Bruenker, Pablo Umana, Christiane Neumann
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The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells comprising a common light chain. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
A T cell activating bispecific antigen binding molecule comprising a first and a second antigen binding moiety, wherein the first antigen binding moiety comprises a first light chain and wherein the first antigen binding moiety is capable of specific binding to an activating T cell antigen, wherein the second antigen binding moiety comprises a second light chain and wherein the second antigen binding moiety is capable of specific binding to a target cell antigen, wherein the amino acid sequence of the first and the second light chain is identical.
The T cell activating bispecific antigen binding molecule of any one of the preceding claims, wherein the activating T cell antigen is CD3.
The T cell activating bispecific antigen binding molecule of any one of the preceding claims, wherein the target cell antigen is selected from the group consisting of:
The T cell activating bispecific antigen binding molecule of any one of the preceding claims, wherein the first and the second light chain is a humanized light chain.
The T cell activating bispecific antigen binding molecule of any one of the preceding claims, wherein the first and the second light chain are capable of use in more than two antigen binding moieties having different antigen specificity.
The T cell activating bispecific antigen binding molecule of any of the preceding claims, wherein the target cell antigen is not BCMA.
A light chain comprising the amino acid sequence of SEQ ID NO:
A light chain comprising the amino acid sequence of SEQ ID NO:
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
A method for identifying a variable heavy chain for use in a bispecific antigen binding molecule specific for a T cell activation antigen and a target cell antigen, comprising the step of screening a combinatorial library comprising variable heavy chains with a light chain comprising the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.