Cd94/nkg2a and/or cd94/nkg2b antibody, vaccine combinations
AssigneeAcademisch Ziekenhuis Leiden (H.O.D.N. Lumc)
InventorsSJOERD VAN DER BURG, THORBALD VAN HALL
Life of this patent
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Abstract
The disclosure provides among others a combination of a vaccine and a CD94/NKG2A and/or a CD94/NKG2B binding antibody for use in the treatment of a subject in need thereof, wherein said vaccine comprises an immunogen for eliciting an immune response against an antigen or a nucleic acid molecule encoding said immunogen.
Claims18
1-15. (canceled)
A method of treating a subject comprising administering a combination of a vaccine and a CD94/NKG2A and/or a CD94/NKG2B binding antibody or a CD94/NKG2A and/or a CD94/NKG2B binding part thereof, said vaccine comprising an immunogen for eliciting an immune response against an antigen or a nucleic acid molecule encoding said immunogen.
A pharmaceutical composition comprising vaccine and a CD94/NKG2A and/or CD94/NKG2B binding antibody or a CD94/NKG2A and/or a CD94/NKG2B binding part thereof, wherein said vaccine comprises an immunogen for eliciting an immune response against an antigen or a nucleic acid molecule encoding said immunogen.
A kit of parts comprising a vaccine composition and a composition comprising a CD94/NKG2A and/or CD94/NKG2B binding antibody or a CD94/NKG2A and/or a CD94/NKG2B binding part thereof, wherein said vaccine comprises an immunogen for eliciting an immune response against an antigen or a nucleic acid molecule encoding said immunogen.
A method for preparing an immune cell containing cell product comprising culturing a collection of cells comprising T-cells and/or NK-cells in the presence of an immunogen and a CD94/NKG2A and/or a CD94/NKG2B antibody or a CD94/NKG2A and/or a CD94/NKG2B binding part thereof.
A method for stimulating an immune response in a subject comprising administering a vaccine and a CD94/NKG2A and/or CD94/NKG2B binding antibody or a CD94/NKG2A and/or a CD94/NKG2B binding part thereof to the subject in need thereof, wherein said vaccine comprises an immunogen for eliciting an immune response against an antigen or a nucleic acid molecule encoding said immunogen.
Dependencies are inferred from the claim text.