Compounds for ph-controlled release of hydrogen sulfide
AssigneesWashington State University, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsMing Xian, Jianming Kang, David J. Lefer
Life of this patent
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Abstract
The embodiments herein generally relates to compounds and methods for releasing H2S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H2S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H2S.
Claims16
A compound having the formula,
- wherein
- R is a hydrogen, alkyl, substituted alkyl, aryl, aralkyl, substituted aryl or a combination thereof;
- R1 is an aryl, alkyl, aralkyl, substituted aryl or a combination thereof;
- R4 is independently at each location a hydrogen, alkyl or a carboxylic acid, wherein at least one R4 is an alkyl or a carboxylic acid;
- n ranges from 1-6, or
- a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer.
A compound having the formula
- wherein
- R1 is aryl, alkyl, aralkyl, and substituted aryl or a combination thereof;
- R2 is an independent hydrogen, or a part of a heterocycle, heterocyclic, or
- heterocyclyl system with R3 optionally substituted, fully saturated or unsaturated,
- aromatic or nonaromatic cyclic group which is a 3 to 7 membered ring system;
- R4 is a alkyl or a carboxylic acid, or
- a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer.
A method of treating a patient that would benefit from controlled H2S administration comprising
- administering to patient a compound having the formula:
- wherein
- R is an independent hydrogen or alkyl, substituted alkyl, aryl, aralkyl, and substituted aryl or a combination thereof;
- R1 is aryl, alkyl, aralkyl, and substituted aryl or a combination thereof;
- R4 is independently at each location a hydrogen, alkyl or a carboxylic acid, wherein at least one R4 is an alkyl or a carboxylic acid;
- n ranges from 1-6, or
- a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer.
A method of treating a patient that would benefit from controlled H2S administration comprising
- administering to patient a compound having the formula
- wherein
- R1 is aryl, alkyl, aralkyl, and substituted aryl or a combination thereof;
- R2 is an independent hydrogen, or a part of a heterocycle, heterocyclic, or heterocyclyl system with R3 optionally substituted, fully saturated or unsaturated, aromatic or nonaromatic cyclic group which is a 3 to 7 membered ring system;
- R4 is a alkyl or a carboxylic acid, or
- a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer.
Dependencies are inferred from the claim text.