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US 2017/0253600 A1Published application
Pyrrolopyrimidines for use in influenza virus infection
AssigneeJanssen Sciences Ireland UC
InventorsTim Hugo Maria JONCKERS, David Craig MC GOWAN, Pierre Jean-Marie Bernard RABOISSON, Werner Constant Johan EMBRECHTS, Jérôme Émile Georges GUILLEMONT
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Abstract
The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
Claims19
A compound of formula (I)
- or a stereoisomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein
- X is N or C optionally substituted by a substituent selected from the group consisting of —CN, —CF3, —C1-3 alkyl-N—C(O)—C1-3 alkyl, —C(O)—NH2, —C(O)—NH—C1-3 alkyl, —C(O)N-(dialkyl) and —CH2—NC(O)—CH3;
- R1 is H or CH3;
- R2 is H or NH2;
- R3 is selected from the group consisting of
- C1-8 alkyl substituted by carboxylic acid;
- C3-8 cycloalkyl substituted by carboxylic acid, —N—C1-3 alkylsulfone, or —N—C(O)—C3-6 heterocyclyl optionally substituted by C1-6 alkyl;
- and
- C3-6 heterocyclyl substituted by —N—C(O)—C3-6 heterocyclyl.
6 more elements
Dependencies are inferred from the claim text.