Heteroaromatic chalcone derivatives and their medical use

A compound of formula (I)

• wherein:
• R1 is C2-6 alkoxy;
• each R2 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —OH, —O(C1-6 alkyl), —O(C1-6 alkyl)-OH, —O(C1-6 alkyl)-O(C1-6 alkyl), —SH, —S(C1-6 alkyl), —S(C1-6 alkyl)-SH, —S(C1-6 alkyl)-S(C1-6 alkyl), —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)(C1-6 alkyl), halogen, —CF3, —CN, —NO2, —N3, —CHO, —CO—(C1-6 alkyl), —COOH, —CO—O—(C1-6 alkyl), —O—CO—(C1-6 alkyl), —CO—NH2, —CO—NH(C1-6 alkyl), —CO—N(C1-6 alkyl)(C1-6 alkyl), —NH—CO—(C1-6 alkyl), —N(C1-6 alkyl)-CO—(C1-6 alkyl), —SO2—NH2, —SO2—NH(C1-6 alkyl), —SO2—N(C1-6 alkyl)(C1-6 alkyl), —NH—SO2—(C1-6 alkyl), or —N(C1-6 alkyl)-SO2—(C1-6 alkyl);
• each R3 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —OH, —O(C1-6 alkyl), —O(C1-6 alkyl)-OH, —O(C1-6 alkyl)-O(C1-6 alkyl), —SH, —S(C1-6 alkyl), —S(C1-6 alkyl)-SH, —S(C1-6 alkyl)-S(C1-6 alkyl), —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)(C1-6 alkyl), halogen, —CF3, —CN, —NO2, —N3, —CHO, —CO—(C1-6 alkyl), —COOH, —CO—O—(C1-6 alkyl), —O—CO—(C1-6 alkyl), —CO—NH2, —CO—NH(C1-6 alkyl), —CO—N(C1-6 alkyl)(C1-6 alkyl), —NH—CO—(C1-6 alkyl), —N(C1-6 alkyl)-CO—(C1-6 alkyl), —SO2—NH2, —SO2—NH(C1-6 alkyl), —SO2—N(C1-6 alkyl)(C1-6 alkyl), —NH—SO2—(C1-6 alkyl), —N(C1-6 alkyl)-SO2—(C1-6 alkyl), optionally substituted aryl or optionally substituted heteroaryl, wherein said aryl or said heteroaryl is optionally substituted with one or more groups independently selected from C1-4 alkyl, halogen, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl);
• B is benzoheteroaryl, wherein the heteroaryl moiety comprised in said benzoheteroaryl is a monocyclic heteroaryl moiety having 5 ring atoms, wherein 1 or 2 ring atoms are each independently selected from oxygen, sulfur or nitrogen and the other ring atoms are carbon atoms;
• m is an integer of 0 to 4;
• and
• n is an integer of 0 to 4;
• or a pharmaceutically acceptable salt, solvate or prodrug thereof.