Heterobicyclic compounds and their use for the treatment of tuberculosis

A compound of the general formula (1):

• or a salt thereof,
• wherein R1 is
• (1) hydrogen,
• (2) amino which may have one or two of the same or different lower alkyl or
• (3) lower alkyl;
• R2 is
• (1) halogen,
• (2) amino which may have one or two of the same or different lower alkyl,
• (3) lower alkyl,
• (4) lower alkoxy or
• (5) hydroxy;
• m is an integer of 0 to 3;
• provided that when m is 2 or 3, R2 may be different from each other;
• X1 is —CH2—, —O—, —N(R5)—, —S—, —SO— or —SO2—;
• R5 is
• (1) hydrogen,
• (2) lower alkyl or
• (3) lower alkanoyl;
• G1 is lower alkylene;
• R3 is
• (1) hydrogen,
• (2) carboxy,
• (3) halogen,
• (4) lower alkyl which may have one or more hydroxy,
• (5) cyano,
• (6) amino which may have one or two substituents independently selected from:
• (a) lower alkyl and
• (b) —C(═O)—R6 or
• (7) —O—R7;
• R6 is
• (1) lower alkoxy or
• (2) lower alkyl which may have amino which may have one or two of the same or different lower alkyl;
• R7 is
• (1) hydrogen,
• (2) amino,
• (3) lower alkanoyl or
• (4) lower alkyl;
• R4 is
• (1) amino which may have one or two of the same or different lower alkyl,
• (2) halogen,
• (3) cyano,
• (4) lower alkyl,
• (5) oxo,
• (6) —O—R8 or
• (7) —O—C(═O)—R9;
• R8 is
• (1) hydrogen,
• (2) lower alkyl,
• (3) —PH(═O)OH or
• (4) benzyl which may have one or more of the same or different lower alkoxy;
• R9 is
• (1) lower alkyl,
• (2) -G2-COOH,
• (3) amino which may have one or two of the same or different lower alkyl,
• (4) lower alkoxy or
• (5) pyrazinyl;
• G2 is lower alkylene;
• n is an integer of 0 to 8;
• provided that when n is 2 or more, each of R4, R8, R9, and G2 may be different from each other and may be substituted on the same carbon atom;
• X2 is N or CH;
• provided that when X2 is CH, H of the group may be substituted with R4 which is defined as above or may be different from the other R4;
• Ring A is
• (1) aryl which may have one or more substituents, or
• (2) heterocyclyl which may have one or more substituents;
• a moiety of formula:
• [Chem. 2]
• represents single bond or double bond.