US 2017/0253564 A1 · 2-Alkyloxy benzene formyl arylamine compound and pharmaceutical use thereof

Abstract

2-alkoxy benzene formyl arylamine compounds and their pharmaceutical salts are disclosed. The compounds can act as sphingomyelin synthase (SMS) inhibitors to treat diseases caused by abnormal increasing of sphingomyelin (SM). The pharmaceutically acceptable salts and pharmaceutical compositions of the compounds are used as active ingredients in drugs which can prevent and cure diseases caused by SM level abnormal increase. These diseases include atherosclerosis, fatty liver, obesity, type diabetes, and other metabolic syndromes.

Claims7

Dependent claims

A 2-alkoxy benzene formyl arylamine compound represented by formula I, and its pharmaceutically acceptable salts, wherein the formula I is:

wherein,
X, Y, and Z are either carbon atom or nitrogen atom, but not carbon atoms at the same time;
G is selected from phenyl group, substituted phenyl groups and naphthyl group;
and when Y and X, or Y and Z both are carbon atoms, G is selected from phenyl group or naphthyl group;
and
R is chosen from hydrogen group, halogen groups, nitro group and alkoxy groups which contain one to four carbon atoms.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/513,340Filed 24 Jul 2015

Priority

CN 201410419334.224 Aug 2014

Published

7 Sep 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07D 213/75
Nitrogen atoms: amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
A61K 31/4406
Non condensed pyridines; Hydrogenated derivatives thereof: only substituted in position 3, e.g. zimeldine
A61K 31/505
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: pyrimidines; Hydrogenated…
A61K 31/5377
1,4-Oxazines, e.g. morpholine: not condensed and containing further heterocyclic rings, e.g. timolol

2-Alkyloxy benzene formyl arylamine compound and pharmaceutical use thereof

Life of this patent

2-Alkyloxy benzene formyl arylamine compound and pharmaceutical use thereof

Life of this patent

Abstract

Claims7