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US 2017/0253554 A1Published application
Cyclopropanecarboxylic acid gpr120 modulators
AssigneeBristol-Myers Squibb Company
InventorsYan Shi, Peter T.W. Cheng, Ying Wang, Sutjano Jusuf, Shiwei Tao, Hao Zhang, Shung C. Wu, Jeffrey A. Robl
Life of this patent
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Abstract
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein coupled receptor modulators which may be used as medicaments
Claims11
The compound of the formula
- or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein:
- R1 is independently selected from:
- phenyl and a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p;
- wherein said phenyl and heteroaryl are substituted with 0-4 R5;
- L1 is independently —CH2CH2—, —CH2OCH2—, —CH2O— or —OCH2—;
- L2 is independently a bond or —CH2—;
- R2, at each occurrence, is independently selected from:
- halogen, C1-6 alkyl substituted with 0-1 Ra, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, and C1-4 haloalkoxy;
- R3 and R4, at each occurrence, are independently selected from the group consisting of H, halogen, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl;
- R5 at each occurrence, is independently selected from:
- halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, —O—C2-6 alkenyl, SO2(C1-4 alkyl), and —(O)0-1—(CH2)0-2—R6;
- alternatively, two R5 groups, when they are attached to two adjacent carbon atoms and together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic or heterocyclic ring comprising carbon atoms and 0-3 heteroatoms selected from N, NRb, O, and S(O)p;
- wherein said heterocycle is substituted with 0-2 Rc;
- R6 is independently selected from:
- C3-6 carbocycle and a 5- to 6-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S;
- wherein said carbocycle and heterocycle are substituted with 0-3 Rc;
- Ra, at each occurrence, is independently selected from:
- C1-4 alkoxy and C(═O)H;
- Rb, at each occurrence, is independently selected from:
- H, C1-4 alkyl, and —(CH2)0-2-phenyl;
- Rc, at each occurrence, is independently selected from:
- halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, C1-4 haloalkoxy, CO2(C1-4 alkyl), and COPh;
- m is independently 0, 1, or 2;
- and
- p is, independently at each occurrence, selected from 0, 1, and 2.
22 more elements
Dependencies are inferred from the claim text.