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US 2017/0253546 A1Published application
Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Izabela K. Sibilska, Rafal R. Sicinski, Lori A. Plum
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Abstract
Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D3, (20S)-1α-hydroxy-2-methylene-vitamin D3, and (5E)-1α,25-dihydroxy-2-methylene-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds including methods of treating and/or preventing bone diseases and disorders.
Claims21
A compound having a formula:
- wherein:
- X1, and X2, which may be the same or different, are each selected from hydrogen or a hydroxy-protecting group.
(canceled)
A compound having a formula:
- wherein:
- X1, and X2, which may be the same or different, are each selected from hydrogen or a hydroxy-protecting group.
Dependencies are inferred from the claim text.