Compounds and compositions for treating hiv with derivatives of betulin
AssigneeGlaxoSmithKline LLC
InventorBrian Alvin Johns
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds characterized by having a structure according to the following Formula I: or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.
Claims17
1-128. (canceled)
A composition comprising a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with GSK1265744, wherein GSK1265744 is a compound of the structure:
- or a pharmaceutically acceptable salt thereof.
A composition comprising a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with GSK1265744, wherein GSK1265744 is a compound of the structure
- or a pharmaceutically acceptable salt thereof.
A composition comprising a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with:
- a) GSK1265744, wherein GSK1265744 is a compound of the structure:
- or a pharmaceutically acceptable salt thereof, and
- b) TMC-278, wherein TMC-278 is a compound of the structure:
A composition comprising a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with:
- a) GSK1265744, wherein GSK1255744 is a compound of the structure:
- or a pharmaceutically acceptable salt thereof, and
- b) TMC-278, wherein TMC-278 is a compound of the structure:
A method of ameliorating an HIV infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with GSK1265744, wherein GSK1265744 is a compound of the structure:
- or a pharmaceutically acceptable salt thereof.
A method of ameliorating an HIV infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with GSK1265744, wherein GSK1265744 is a compound of the structure:
- or a pharmaceutically acceptable salt thereof.
A method of ameliorating an HIV infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with:
- a) GSK1265744, wherein GSK1265744 is a compound of the structure:
- or a pharmaceutically acceptable salt thereof, and
- b) TMC-278, wherein TMC-278 is a compound of the structure:
A method of ameliorating an HIV infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the structure:
- or a pharmaceutically acceptable salt thereof,
- in combination with:
- a) GSK1265744, wherein GSK1265744 is a compound of the structure:
- or a pharmaceutically acceptable salt thereof, and
- b) TMC-278, wherein TMC-278 is a compound of the structure:
Dependencies are inferred from the claim text.