Methods for evaluating renal injury and renal failure using urine levels of chitinase-3-like protein 1

A method for evaluating renal status in a subject, comprising:

• performing an assay on a urine sample obtained from the subject, wherein the assay is configured to detect Chitinase-3-like protein 1 in the urine sample, by introducing the urine sample into an assay instrument that (i) contacts all or a portion of the urine sample with a binding reagent which specifically binds for detection Chitinase-3-like protein 1, and (ii) generates an assay result indicative of binding of Chitinase-3-like protein 1 to the binding reagent;
• correlating the assay result to the renal status of the subject by using the assay result to a likelihood of to assign the subject to a predetermined subpopulation of individuals having a known predisposition of future acute renal failure (ARF) within 24 hours of the time at which the body fluid sample was obtained from the subject;
• and,
• treating the subject based on the predetermined subpopulation of individuals to which the patient is assigned, wherein the treatment comprises performing renal replacement therapy on the subject.