Method and panel for determining acute kidney injury

A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery comprising determining in a biological sample from the mammal a sample value for at least one of IL-6 or hFABP concentration, or for the ratio of IL-6 concentration to IL-10 concentration, either pre-operatively or within 6 hours post-operatively;

• determining a reference value for IL-6 or hFABP concentration, or for the ratio of IL-6 concentration to IL-10 concentration in a corresponding cardiac surgical population;
• comparing the at least one sample value to a corresponding reference value;
• and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is equal to or greater than the corresponding reference value.