Method and system to predict response to pain treatments
AssigneePathway Genomics
InventorsAndria Del Tredici, Russell Kuo-fu Chan, Guangdan Zhu, K. David Becker, Tanya Moreno
Life of this patent
Estimating the term…
Abstract
The present inventions relates to methods and assays to predict the response of an individual to an analgesic treatment and to a method to improve medical treatment of a disorder, which is responsive to treatment with an analgesic.
Claims32
A method for predicting an individual's likely response to a pain medication, comprising genotyping genetic variations in an individual to determine:
- 1) a categorical grade to an individual's likely ability to metabolize a particular pain medication and a categorical grade for a pain medication's potential efficacy with respect to the individual,
- 2) aggregating the categorical grades, and thereafter identifying the least positive grade as the recommended prediction for the individual.
The method of claim, wherein the narcotic is selected from alfentanil, alphaprodine, anileridine, bezitramide, buprenorphine, butorphanol, codeine, dezocine, dihydrocodeine, diphenoxylate, ethylmorphine, fentanyl, heroin, hydrocodone, hydromorphone, isomethadone, levomethorphan, levorphanol, meptazinol, metazocine, metopon, morphine, nalbuphine, nalmefene, opium extracts, opium fluid extracts, pentazocine, propoxyphene, powdered opium, granulated opium, raw opium, tincture of opium, oxycodone, oxymorphone, pethidine(meperidine), phenazocine, piminodine, racemic methadone, racemethorphan, racemorphan, sufentanil, thebaine, or tramadol.
A computerized system for predicting an individual's likely response to a pain medication, comprising accessing the individual's genotype information, and determining:
- 1) a categorical grade to an individual's likely ability to metabolize a particular pain medication and a categorical grade for a pain medication's potential efficacy with respect to the individual,
- 2) aggregating the categorical grades, and thereafter identifying the least positive grade as the recommended prediction for the individual.
Dependencies are inferred from the claim text.