Urea/carbamates faah magl or dual faah/magl inhibitors and uses thereof

A compound of formula IB

• wherein
• R1=—H, -alkyl;
• R2=—H, -alkyl, where alkyl is saturated C1-10 hydrocarbon, which may be straight or branched chain;
• Li is selected from a double bond, —(CH2)n—, -0-, —CH═CH—, —CONH—, —S—, —S(=0)-, —S02—, —NH—, and —NRi-, where n=0-6;
• Ai is selected from aryl, heteroaryl, benzhydryl, fluorenyl, aryl(aryl)methyl,
• aryl(phenyl)methyl, aryl(alkyl)methyl, aryl(cycloalkyl)methyl and each aryl, heteroaryl or fluorenyl group may be unsubstituted, mono or di-substituted with following moieties;
• —N02, —CN, —OH, -alkyl, —O-alkyl, -halogen, —CF3, —OCF3, —S-alkyl, —OPh, -Ph-S(0)-alkyl, —S02-alkyl, —C02-alkyl, —COOH, —NHR3, —NR3P, —NR3S02R4, —N02, —CN, —CONR3R4;
• morpholino;
• thiomorpholino, 1,1-dioxothiomorpholine, and oxothiomorpholino,
• R3 and R4 are independently selected from —H, -alkyl, and cycloalkyl;
• R5 is selected from H, OH, and halogen;
• and
• Rs is selected from H, —CN, —OH, —OMe, —CF3, —OCF3, —OBn, —CONH2, —S02NH2, and —COOH.

A compound of Formula II

• wherein
• M=0 or S;
• Z=O, NH, or none;
• when Z=none B2 is directly attached to C=M;
• n=1-2;
• L2 is selected from
• —O—, —CH═CH—, —CONH,
• —S—, —S(O)—, SO2, —NH—, n=0-2;
• A2 is selected from aryl, heteroaryl, fluoren-9-yl, aryl(alkyl)methyl, aryl(cycloalkyl)methyl, heteroaryl(alkyl)methyl, or heteroaryl(cycloalkyl)methyl and each aryl, heteroaryl or fluore-9-nyl group may be unsubstituted, or substituted with one or two moieties as defined below;
• —OH, -alkyl, —O-alkyl, -halogen, —CF3, —OCF3, —S-alkyl, —OPh, -Ph-S(0)-alkyl, —S02-alkyl, —C02-alkyl, —COOH, —NHR, —NR3P, —NR3S02R4, —N02, —CN, —CONR3R4, -alkynyl, morpholino, thiomorpholino, 1,1-dioxothiomorpholine, 1-oxothiomorpholino;
• R3 and R4 are independently selected from —H;
• -alkyl, and cycloalkyl;
• B2 is selected from aryl and heteroaryl groups, and each aryl or heteroaryl group may be unsubstituted or substituted with one or two moieties as defined below:
• -halogen —NO2, —CN, —OH, —NH2, —CONH2, —O-aryl, —CF3, —OCF3, —OCF2H, —SCF3;
• B3 is selected from
• wherein Wi is either CH or N;
• W2 is selected from CH2, O, S02, CHAr, and NAr;
• Ar is aryl or heteroaryl containing 1 to 3 heteroatoms;
• R5 is selected from —H, -halogen —NO2, —CN, —OH, -Ph, —COOMe;
• —NH2, —CONH2, —O-aryl, -CF3, —OCF3, —OCF2H, and —SCF3;
• R6 is selected from monocyclic heteroaryl ring containing 1 to 3 heteroatoms, and the heteroaryl ring is optionally substituted with one or two groups, as defined below:
• —CN, —OH, —OMe, —CF3, —OCF3, —OBn, —CONH2, —S02NH2, —COOH -halogen, or
• wherein M is selected from O and S.

A compound of Formula III

• wherein
• X=CH or N;
• M=0 or S;
• Z=O, NH, or none;
• when Z=none B3 is directly attached to C=M;
• n=1-3
• L3 is selected from —(CH2), -j-0(CH2)n-, —C(═O)— when X is N, or from —(CH2),0-, —0-, —CH═CH—, —CONH—, —NH—, —NRi- when X is CH, where n=0-3;
• A3 is selected from aryl, heteroaryl, fluoren-9-yl, and each aryl, heteroaryl or fluoren-9-yl group may be unsubstituted, or substituted with one or two moieties as defined below;
• -halogen —N02, —CN, —OH, —NH2, —CONH2, —C02Me;
• -alkyl, -Oalkyl, -halogen, —CF3, —OCF3, —Salkyl, —OCH2Ph, -Ph, —S(0)-alkyl, —S02-alkyl, —C02-alkyl, —COOH, —NHR3, —NR3P, —NR3S02P, —N02, —CN, —CONR3R4;
• morpholino;
• thiomorpholino, 1,1-dioxothiomorpholine, oxothiomorpholino;
• R3 and R4 are independently selected from —H or -alkyl, cycloalkyl;
• B3 can be selected from aryl or heteroaryl groups, and each aryl or heteroaryl group may be unsubstituted or substituted with one or two moieties as defined below:
• -halogen, —CN, —OH, —NH2, —C02Me, —CONH2, —OMe;
• or
• B3 is also selected from
• wherein Wi is either CH or N;
• Ar can be aryl or heteroaryl containing 1 to 3 heteroatoms;
• R5 is selected from —H, -halogen, —CN, —OH, —NH2, —C02Me, —CONH2, —OMe;
• is selected from monocyclic heteroaryl ring containing 1 to 3 heteroatoms, and the heteroaryl ring can be substituted with one or two groups as defined below,
• —CN, —OH, OMe, CF3, —OCH2Ph, —CONH2, —S02NH2, —COOH, halogen or
• wherein M is selected from O and S.