Bipartite and tripartite signaling immune cells
AssigneeBaylor College of Medicine
InventorsJuan Fernando Vera Valdes, Ann Marie Leen, Sujita Sukumaran
Life of this patent
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Abstract
Embodiments of the disclosure include compositions and methods effective for immunotherapy, such as for cancer. The embodiments include cells that recognize a combination of two signals or three signals present at the tumor microenvironment. In certain embodiments, the signals for antigen stimulation, co-stimulation, and cytokine signaling act through separate molecules, although in certain embodiments the signals for antigen stimulation and co-stimulation are transmitted through the same molecule.
Claims39
A composition, comprising an engineered immune cell that separately expresses at least two of:
- 1) a molecule that provides antigen recognition for the cell;
- 2) a molecule that provides co-stimulation for the cell;
- and
- 3) a molecule that provides cytokine stimulation for the cell,
- wherein there is one of the following:
- a) the molecule that provides antigen recognition for the cell and the molecule that provides co-stimulation for the cell are the same molecule;
- or
- b) the molecule that provides antigen recognition for the cell and the molecule that provides co-stimulation for the cell are different molecules.
A composition, comprising an engineered immune cell that separately expresses at least two of:
- a) a molecule that provides costimulatory signaling to the cell upon recognition of a first soluble factor;
- b) a molecule that provides cytokine signaling to the cell upon recognition of a second soluble factor;
- and
- c) a molecule that provides antigen recognition for the cell upon recognition of a antigen, wherein the molecule is native to the cell or artificial to the cell,
- wherein when the molecule that provides antigen recognition for the cell is an artificial receptor that is a chimeric antigen receptor, the chimeric antigen receptor lacks a costimulatory domain.
A composition, comprising an engineered immune cell that separately expresses at least two of:
- a) a molecule that provides costimulatory signaling to the cell upon recognition of a first soluble factor;
- b) a molecule that provides cytokine signaling to the cell upon recognition of a second soluble factor;
- and
- c) a molecule that provides antigen recognition for the cell upon recognition of an antigen, wherein the molecule is native to the cell or artificial to the cell,
- wherein when the molecule that provides antigen recognition for the cell is an artificial receptor, the artificial receptor lacks a costimulatory domain.
Dependencies are inferred from the claim text.