Interleukin-15 Compositions and Uses Thereof
AssigneeArmo Biosciences, Inc.
InventorScott McCauley
Life of this patent
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Abstract
Interleukin-15 muteins and other interleukin-15-related molecules are described, as well as methods of identifying interleukin-15 muteins and other interleukin-15-related molecules. Also described herein are modifications of the foregoing, which modifications may enhance a property (e.g., half-life) of the muteins or other molecules compared to human interleukin-15. Pharmaceutical compositions and methods of use are also described herein.
Claims132
A peptide comprising:
- a) a Helix A, b) an A/B Inter-helix Junction, c) a Helix B, d) a B/C Inter-helix Junction, e) a Helix C, f) a C/D Inter-helix Junction and g) a Helix D;
- and wherein the peptide further comprises at least one amino acid substitution, addition or deletion to one or more of a)-g).
A peptide comprising the amino acid sequence of SEQ ID NO:3, wherein the peptide comprises at least one amino acid substitution of a surface-exposed amino acid residue;
- and wherein the substitution has at least one of the following effects:
- (a) improves at least one physical property of the peptide, (b) does not adversely affect the immunogenicity of the peptide, or (c) does not adversely affect the bioactivity of the peptide.
A peptide comprising at least 90% sequence identity to the amino acid sequence of SEQ ID NO:3, wherein the peptide has a least one of the following characteristics:
- (a) is not more immunogenic than the peptide of SEQ ID NO:3, (b) has a bioactivity at least equal to the bioactivity of the peptide of SEQ ID NO:3, (c) has an improvement in at least one physical property of the peptide of SEQ ID NO:3.
The kit of claim 86, further comprising a second sterile container comprising at least one additional prophylactic or therapeutic agent.
A peptide comprising the amino acid sequence of SEQ ID NO:3, wherein the peptide comprises at least one amino acid substitution at one of the following positions:
- 1, 3, 13-15, 17-29, 33, 34, 36-39, 41, 45, 48, 49, 51-58, 60, 67, 71-84, 86, 87, 89-98, 101, 102, 104, 113, or 114.
Dependencies are inferred from the claim text.