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US 2017/0224806 A1Published application
Recombinant bacterium and methods of antigen and nucleic acid delivery
AssigneeArizona Board of Regents for and on behalf of Arizona State University
InventorsRoy Curtiss, III, Wei Kong
Life of this patent
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Abstract
The present invention provides a recombinant bacterium and methods of using the recombinant bacterium to induce an immune response.
Claims17
-20. (canceled)
A recombinant Salmonella bacterium, wherein the bacterium:
- (a) comprises regulated expression of at least one nucleic acid encoding an antigen;
- (b) comprises at least one mutation allowing endosomal escape, such that the antigen is capable of being delivered to the cytosol and inducing host cellular immunity;
- (c) is capable of regulated delayed attenuation;
- and
- (d) is capable of regulated delayed lysis.
2 more elements
Dependencies are inferred from the claim text.