Control of varroa mite infestation
AssigneesThe University Court of the University of Aberdeen, The Secretary of State for Enviroment Food and Rural Affairs
InventorsAlan Stuart Bowman, Ewan Mclnnes Campbell, Giles Elliott Budge
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Abstract
Nucleic acid agents for reducing or removing infestations of the Varroa destructor mite are described. Compositions comprising the nucleic acid agents and methods for controlling mite infestations using the nucleic acid agents and compositions are also disclosed.
Claims33
An isolated non-natural nucleic acid agent comprising a nucleic acid sequence that is capable of downregulating the expression of a gene of the Varroa destructor mite, wherein the gene encodes Monoamine Oxidase (MOA;
- GenBank accession number ADDG01053234.1), Acetylcholinesterase (AChE;
- GenBank accession number ADDG01069748.1), vATPase subunit C (vATPc;
- GenBank accession number ADDG01035752.1, GABA-receptor alpha subunit (GABA-Rα;
- GenBank accession number ADDG01060981.1), Chitin Synthase 1 (CHS-1;
- GenBank accession number ADDG01037469.1), Pyruvate Kinase (PyK;
- GenBank accession number ADDG01095321.1), alpha Tubulin (αTUB;
- GenBank accession number ADDG01073340.1), Prothoracicostatic peptide precursor (PTTH;
- GenBank accession number ADDG01000788.1), Crustacean hyperglycaemic hormone (CHH;
- GenBank accession number ADDG01078386.1), or Glutathione transferase mu1 (GSTμ1;
- GenBank accession number ADDG01001667.1).
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An isolated nucleic acid concatemer comprising at least a first nucleic acid sequence and a second nucleic acid sequence;
- wherein the first nucleic acid sequence is capable of down-regulating the expression of a first gene of the Varroa destructor mite, and the second nucleic acid sequence is capable of down-regulating the expression of a second gene of the Varroa destructor mite;
- wherein the concatemer optionally further comprises a third nucleic acid sequence, wherein the third nucleic acid sequence is capable of down-regulating the expression of a third gene of the Varroa destructor mite.
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Dependencies are inferred from the claim text.