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US 2016/0355809 A1Published application
MicroRNA-Based Methods and Assays for Osteosarcoma
Assignees3-D Matrix, Ltd., National Cancer Center
InventorsTakahiro Ochiya, Tomohiro Fujiwara
Life of this patent
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Abstract
Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
Claims19
1-21. (canceled)
A method of screening for osteosarcoma, comprising:
- performing on a tissue sample from a subject an assay specifically capable of detecting at least one microRNA (miRNA) selected from the group consisting of miR-1, miR-10b, and miR-133a, wherein detection by the assay of the presence in the sample of the at least one miRNA indicates the subject is at risk of having osteosarcoma.
25-27. (canceled)
Dependencies are inferred from the claim text.