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AssigneesCentenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Wenkart Foundation
InventorsJennifer Gamble, Mathew Vadas, Gregory Goodall, Jennifer Young
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The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.
A method for increasing the expression of VE-cadherin protein in a cell or tissue of a subject, the method comprising administering to the subject, or a cell or tissue derived therefrom, an effective amount of one or more antagonists of a miRNA comprising a seed region comprising the sequence UCACAGU (SEQ ID No. 37).
A method for decreasing endothelial cell permeability in a cell or tissue of a subject, the method comprising administering to the subject, or a cell or tissue derived therefrom, an effective amount of one or more antagonists of a miRNA comprising a seed region comprising the sequence UCACAGU (SEQ ID No. 37).
A method for decreasing the expression of VE-cadherin protein in a cell or tissue of a subject, the method comprising administering to the subject, or a cell or tissue derived therefrom, an effective amount of a miRNA comprising a seed region comprising the sequence UCACAGU (SEQ ID No. 37).
A method for increasing endothelial cell permeability in a cell or tissue of a subject, the method comprising administering to the subject, or a cell or tissue derived therefrom, an effective amount of a miRNA comprising a seed region comprising the sequence UCACAGU (SEQ ID No. 37).
Dependencies are inferred from the claim text.