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US 2016/0355608 A1Published application
Heterodimeric antibodies that bind cd3 and tumor antigens
AssigneeXencor, Inc.
InventorsMatthew J. Bernett, Gregory Moore, John Desjarlais, Seung Chu, Rumana Rashid, Umesh Muchhal, Sung-Hyung Lee
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Abstract
The present invention is directed to novel heterodimeric antibodies.
Claims7
-50. (canceled)
A heterodimeric antibody comprising:
- a) a first monomer comprising:
- i) a first Fc domain;
- ii) an anti-CD3 scFv comprising a scFv variable light domain, an scFv linker and a scFv variable heavy domain;
- wherein said scFv is covalently attached to the N-terminus of said Fc domain using a domain linker;
- b) a second monomer comprising a heavy chain comprising:
- i) a heavy variable domain;
- and
- ii) a heavy chain constant domain comprising a second Fc domain;
- and
- c) a light chain comprising a variable light domain and a variable light constant domain;
- wherein said anti-CD3 scFv is selected from the group consisting of anti-CD3 H1.32_L1.47 (SEQ ID NO:18), anti-CD3 H1.89_L1.47 (SEQ ID NO:27), anti-CD3 H1.90_L1.47 (SEQ ID NO:36) and anti-CD3 H1.33_L1.47 (SEQ ID NO:45), and said heavy variable domain and said light variable domain bind a TTA.
8 more elements
-72. (canceled)
Dependencies are inferred from the claim text.