Anti-pcsk9 antibodies, formulations, dosing, and methods of use

An anti-PCSK9 antibody comprising a heavy chain and light chain variable domain comprising six hypervariable region (HVR) sequences:

• (i) HVR-H1 comprising GFTFX1X2X3X4IH (SEQ ID NO:28), wherein X1 is S or T;
• X2 is G, R or S;
• X3 is H, T or Y;
• X4 is A or T;
• (ii) HVR-H2 comprising RISPANGNTNYADSVKG (SEQ ID NO:4);
• (iii) HVR-H3 comprising WIGSRELYIMDY (SEQ ID NO:5);
• (iv) HVR-L1 comprising RASQDVSX1AVA (SEQ ID NO:29), wherein X1 is S or T;
• (v) HVR-L2 comprising SASX1LYS (SEQ ID NO:30), wherein X1 is F or S;
• and
• (vi) HVR-L3 comprising QQAYX1X2X3X4T (SEQ ID NO:37), wherein X1 is P, R or T;
• X2 is A, I, S or T;
• X3 is L, P or Q;
• X4 is A, H, P or S.